DRUGS, MEDICINAL AND BIOLOGICAL SUBSTANCES CAUSING ADVERSE EFFECTS IN THERAPEUTIC USE (E930-E949)

• Includes: correct drug properly administered in therapeutic or prophylactic dosage, as the cause of any adverse effect including allergic or hypersensitivity reactions
• Excludes: accidental overdose of drug and wrong drug given or taken in error (E850.0-E858.9)
  • accidents in the technique of administration of drug or biological substance such as accidental puncture during injection, or contamination of drug (E870.0-E876.9)
  • administration with suicidal or homicidal intent or intent to harm, or in circumstances classifiable to E980-E989 (E950.0-E950.5, E962.0, E980.0-E980.5)
• See Alphabetic Index for more complete list of specific drugs to be classified under the fourth-digit subdivisions. The American Hospital Formulary numbers can be used to classify new drugs listed by the American Hospital Formulary Service (AHFS). See appendix C.
• E930 Antibiotics
  • Excludes: that used as eye, ear, nose, and throat [ENT], and local anti-infectives (E946.0-E946.9)
  • E930.0 Penicillins
    • Natural
    • Synthetic
    • Semisynthetic, such as:
      • ampicillin
      • cloxacillin
      • nafcillin
      • oxacillin
  • E930.1 Antifungal antibiotics
    • Amphotericin B
    • Griseofulvin
    • Hachimycin [trichomycin]
    • Nystatin
  • E930.2 Chloramphenicol group
    • Chloramphenicol
    • Thiamphenicol
  • E930.3 Erythromycin and other macrolides
    • Oleandomycin
    • Spiramycin
  • E930.4 Tetracycline group
    • Doxycycline
    • Minocycline
    • Oxytetracycline
  • E930.5 Cephalosporin group
    • Cephalexin
    • Cephaloglycin
    • Cephaloridine
    • Cephalothin
  • E930.6 Antimycobacterial antibiotics
    • Cycloserine
    • Kanamycin
    • Rifampin
    • Streptomycin
  • E930.7 Antineoplastic antibiotics
    • Actinomycins, such as:
      • Cactinomycin
      • Dactinomycin
      • Bleomycin
      • Daunorubicin
      • Mitomycin
    • Excludes: other antineoplastic drugs (E933.1)
  • E930.8 Other specified antibiotics
  • E930.9 Unspecified antibiotic
• E931 Other anti-infectives
  • Excludes: ENT, and local anti-infectives (E946.0-E946.9)
  • E931.0 Sulfonamides
    • Sulfadiazine
    • Sulfafurazole
    • Sulfamethoxazole
  • E931.1 Arsenical anti-infectives
  • E931.2 Heavy metal anti-infectives
    • Compounds of:
      • antimony
      • bismuth
      • lead
      • mercury
    • Excludes: mercurial diuretics (E944.0)
  • E931.3 Quinoline and hydroxyquinoline derivatives
    • Chiniofon
    • Diiodohydroxyquin
    • Excludes: antimalarial drugs (E931.4)
  • E931.4 Antimalarials and drugs acting on other blood protozoa
    • Chloroquine phosphate
    • Cycloguanil
    • Primaquine
    • Proguanil [chloroguanide]
    • Pyrimethamine
    • Quinine (sulphate)
  • E931.5 Other antiprotozoal drugs
    • Emetine
  • E931.6 Anthelmintics
    • Hexylresorcinol
    • Male fern oleoresin
    • Piperazine
    • Thiabendazole
  • E931.7 Antiviral drugs
    • Methisazone
    • Excludes: amantadine (E936.4)
      • cytarabine (E933.1)
      • idoxuridine (E946.5)
  • E931.8 Other antimycobacterial drugs
    • Ethambutol
    • Ethionamide
    • Isoniazid
    • Para-aminosalicylic acid derivatives
    • Sulfones
  • E931.9 Other and unspecified anti-infectives
    • Flucytosine
    • Nitrofuran derivatives
• E932 Hormones and synthetic substitutes
  • E932.0 Adrenal cortical steroids
    • Cortisone derivatives
    • Desoxycorticosterone derivatives
    • Fluorinated corticosteroids
  • E932.1 Androgens and anabolic congeners
    • Nandrolone phenpropionate
    • Oxymetholone
    • Testosterone and preparations
  • E932.2 Ovarian hormones and synthetic substitutes
    • Contraceptives, oral
    • Estrogens
    • Estrogens and progestogens combined
    • Progestogens
  • E932.3 Insulins and antidiabetic agents
    • Acetohexamide
    • Biguanide derivatives, oral
    • Chlorpropamide
    • Glucagon
    • Insulin
    • Phenformin
    • Sulfonylurea derivatives, oral
    • Tolbutamide
    • Excludes: adverse effect of insulin administered for shock therapy (E879.3)
  • E932.4 Anterior pituitary hormones
    • Corticotropin
    • Gonadotropin
    • Somatotropin [growth hormone]
  • E932.5 Posterior pituitary hormones
    • Vasopressin
    • Excludes: oxytocic agents (E945.0)
  • E932.6 Parathyroid and parathyroid derivatives
  • E932.7 Thyroid and thyroid derivatives
    • Dextrothyroxine
    • Levothyroxine sodium
    • Liothyronine
    • Thyroglobulin
  • E932.8 Antithyroid agents
    • Iodides
    • Thiouracil
    • Thiourea
  • E932.9 Other and unspecified hormones and synthetic substitutes
• E933 Primarily systemic agents
  • E933.0 Antiallergic and antiemetic drugs
    • Antihistamines
    • Chlorpheniramine
    • Diphenhydramine
    • Diphenylpyraline
    • Thonzylamine
    • Tripelennamine
    • Excludes: phenothiazine-based tranquilizers (E939.1)
  • E933.1 Antineoplastic and immunosuppressive drugs
    • Azathioprine
    • Busulfan
    • Chlorambucil
    • Cyclophosphamide
    • Cytarabine
    • Fluorouracil
    • Mechlorethamine hydrochloride
    • Mercaptopurine
    • Triethylenethiophosphoramide [thio-TEPA]
    • Excludes: antineoplastic antibiotics (E930.7)
  • E933.2 Acidifying agents
  • E933.3 Alkalizing agents
  • E933.4 Enzymes, not elsewhere classified
    • Penicillinase
  • E933.5 Vitamins, not elsewhere classified
    • Vitamin A
    • Vitamin D
    • Excludes: nicotinic acid (E942.2)
      • vitamin K (E934.3)
  • E933.8 Other systemic agents, not elsewhere classified
    • Heavy metal antagonists
  • E933.9 Unspecified systemic agent
• E934 Agents primarily affecting blood constituents
  • E934.0 Iron and its compounds
    • Ferric salts
    • Ferrous sulphate and other ferrous salts
  • E934.1 Liver preparations and other antianemic agents
    • Folic acid
  • E934.2 Anticoagulants
    • Coumarin
    • Heparin
    • Phenindione
    • Prothrombin synthesis inhibitor
    • Warfarin sodium
  • E934.3 Vitamin K [phytonadione]
  • E934.4 Fibrinolysis-affecting drugs
    • Aminocaproic acid
    • Streptodornase
    • Streptokinase
    • Urokinase
  • E934.5 Anticoagulant antagonists and other coagulants
    • Hexadimethrine bromide
    • Protamine sulfate
  • E934.6 Gamma globulin
  • E934.7 Natural blood and blood products
    • Blood plasma
    • Human fibrinogen
    • Packed red cells
    • Whole blood
  • E934.8 Other agents affecting blood constituents
    • Macromolecular blood substitutes
  • E934.9 Unspecified agent affecting blood constituents
• E935 Analgesics, antipyretics, and antirheumatics
  • E935.0 Heroin
    • Diacetylmorphine
  • E935.1 Methadone
  • E935.2 Other opiates and related narcotics
    • Codeine [methylmorphine]
    • Morphine
    • Opium (alkaloids)
    • Meperidine [pethidine]
  • E935.3 Salicylates
    • Acetylsalicylic acid [aspirin]
    • Amino derivatives of salicylic acid
    • Salicylic acid salts
  • E935.4 Aromatic analgesics, not elsewhere classified
    • Acetanilid
    • Paracetamol [acetaminophen]
    • Phenacetin [acetophenetidin]
  • E935.5 Pyrazole derivatives
    • Aminophenazone [aminopyrine]
    • Phenylbutazone
  • E935.6 Antirheumatics [antiphlogistics]
    • Gold salts
    • Indomethacin
    • Excludes: salicylates (E935.3)
      • steroids (E932.0)
  • E935.7 Other non-narcotic analgesics
    • Pyrabital
  • E935.8 Other specified analgesics and antipyretics
    • Pentazocine
  • E935.9 Unspecified analgesic and antipyretic
• E936 Anticonvulsants and anti-Parkinsonism drugs
  • E936.0 Oxazolidine derivatives
    • Paramethadione
    • Trimethadione
  • E936.1 Hydantoin derivatives
    • Phenytoin
  • E936.2 Succinimides
    • Ethosuximide
    • Phensuximide
  • E936.3 Other and unspecified anticonvulsants
    • Beclamide
    • Primidone
  • E936.4 Anti-Parkinsonism drugs
    • Amantadine
    • Ethopropazine [profenamine]
    • Levodopa [L-dopa]
• E937 Sedatives and hypnotics
  • E937.0 Barbiturates
    • Amobarbital [amylobarbitone]
    • Barbital [barbitone]
    • Butabarbital [butabarbitone]
    • Pentobarbital [pentobarbitone]
    • Phenobarbital [phenobarbitone]
    • Secobarbital [quinalbarbitone]
    • Excludes: thiobarbiturates (E938.3)
  • E937.1 Chloral hydrate group
  • E937.2 Paraldehyde
  • E937.3 Bromine compounds
    • Bromide
    • Carbromal (derivatives)
  • E937.4 Methaqualone compounds
  • E937.5 Glutethimide group
  • E937.6 Mixed sedatives, not elsewhere classified
  • E937.8 Other sedatives and hypnotics
  • E937.9 Unspecified
    • Sleeping:
      • drug NOS
      • pill NOS
      • tablet NOS
• E938 Other central nervous system depressants and anesthetics
  • E938.0 Central nervous system muscle-tone depressants
    • Chlorphenesin (carbamate)
    • Mephenesin
    • Methocarbamol
  • E938.1 Halothane
  • E938.2 Other gaseous anesthetics
    • Ether
    • Halogenated hydrocarbon derivatives, except halothane
    • Nitrous oxide
  • E938.3 Intravenous anesthetics
    • Ketamine
    • Methohexital [methohexitone]
    • Thiobarbiturates, such as thiopental sodium
  • E938.4 Other and unspecified general anesthetics
  • E938.5 Surface and infiltration anesthetics
    • Cocaine
    • Lidocaine [lignocaine]
    • Procaine
    • Tetracaine
  • E938.6 Peripheral nerve- and plexus-blocking anesthetics
  • E938.7 Spinal anesthetics
  • E938.9 Other and unspecified local anesthetics
• E939 Psychotropic agents
  • E939.0 Antidepressants
    • Amitriptyline
    • Imipramine
    • Monoamine oxidase [MAO] inhibitors
  • E939.1 Phenothiazine-based tranquilizers
    • Chlorpromazine
    • Fluphenazine
    • Phenothiazine
    • Prochlorperazine
    • Promazine
  • E939.2 Butyrophenone-based tranquilizers
    • Haloperidol
    • Spiperone
    • Trifluperidol
  • E939.3 Other antipsychotics, neuroleptics, and major tranquilizers
  • E939.4 Benzodiazepine-based tranquilizers
    • Chlordiazepoxide
    • Diazepam
    • Flurazepam
    • Lorazepam
    • Medazepam
    • Nitrazepam
  • E939.5 Other tranquilizers
    • Hydroxyzine
    • Meprobamate
  • E939.6 Psychodysleptics [hallucinogens]
    • Cannabis (derivatives)
    • Lysergide [LSD]
    • Marihuana (derivatives)
    • Mescaline
    • Psilocin
    • Psilocybin
  • E939.7 Psychostimulants
    • Amphetamine
    • Caffeine
    • Excludes: central appetite depressants (E947.0)
  • E939.8 Other psychotropic agents
  • E939.9 Unspecified psychotropic agent
• E940 Central nervous system stimulants
  • E940.0 Analeptics
    • Lobeline
    • Nikethamide
  • E940.1 Opiate antagonists
    • Levallorphan
    • Nalorphine
    • Naloxone
  • E940.8 Other specified central nervous system stimulants
  • E940.9 Unspecified central nervous system stimulant
• E941 Drugs primarily affecting the autonomic nervous system
  • E941.0 Parasympathomimetics [cholinergics]
    • Acetylcholine
    • Anticholinesterase:
      • organophosphorus
      • reversible
    • Pilocarpine
  • E941.1 Parasympatholytics [anticholinergics and antimuscarinics] and spasmolytics
    • Atropine
    • Homatropine
    • Hyoscine [scopolamine]
    • Quaternary ammonium derivatives
    • Excludes: papaverine (E942.5)
  • E941.2 Sympathomimetics [adrenergics]
    • Epinephrine [adrenalin]
    • Levarterenol [noradrenalin]
  • E941.3 Sympatholytics [antiadrenergics]
    • Phenoxybenzamine
    • Tolazoline hydrochloride
  • E941.9 Unspecified drug primarily affecting the autonomic nervous system
• E942 Agents primarily affecting the cardiovascular system
  • E942.0 Cardiac rhythm regulators
    • Practolol
    • Procainamide
    • Propranolol
    • Quinidine
  • E942.1 Cardiotonic glycosides and drugs of similar action
    • Digitalis glycosides
    • Digoxin
    • Strophanthins
  • E942.2 Antilipemic and antiarteriosclerotic drugs
    • Cholestyramine
    • Clofibrate
    • Nicotinic acid derivatives
    • Sitosterols
    • Excludes: dextrothyroxine (E932.7)
  • E942.3 Ganglion-blocking agents
    • Pentamethonium bromide
  • E942.4 Coronary vasodilators
    • Dipyridamole
    • Nitrates [nitroglycerin]
    • Nitrites
    • Prenylamine
  • E942.5 Other vasodilators
    • Cyclandelate
    • Diazoxide
    • Hydralazine
    • Papaverine
  • E942.6 Other antihypertensive agents
    • Clonidine
    • Guanethidine
    • Rauwolfia alkaloids
    • Reserpine
  • E942.7 Antivaricose drugs, including sclerosing agents
    • Monoethanolamine
    • Zinc salts
  • E942.8 Capillary-active drugs
    • Adrenochrome derivatives
    • Bioflavonoids
    • Metaraminol
  • E942.9 Other and unspecified agents primarily affecting the cardiovascular system
• E943 Agents primarily affecting gastrointestinal system
  • E943.0 Antacids and antigastric secretion drugs
    • Aluminum hydroxide
    • Magnesium trisilicate
  • E943.1 Irritant cathartics
    • Bisacodyl
    • Castor oil
    • Phenolphthalein
  • E943.2 Emollient cathartics
    • Sodium dioctyl sulfosuccinate
  • E943.3 Other cathartics, including intestinal atonia drugs
    • Magnesium sulfate
  • E943.4 Digestants
    • Pancreatin
    • Papain
    • Pepsin
  • E943.5 Antidiarrheal drugs
    • Bismuth subcarbonate
    • Kaolin
    • Pectin
    • Excludes: anti-infectives (E930.0-E931.9)
  • E943.6 Emetics
  • E943.8 Other specified agents primarily affecting the gastrointestinal system
  • E943.9 Unspecified agent primarily affecting the gastrointestinal system
• E944 Water, mineral, and uric acid metabolism drugs
  • E944.0 Mercurial diuretics
    • Chlormerodrin
    • Mercaptomerin
    • Mercurophylline
    • Mersalyl
  • E944.1 Purine derivative diuretics
    • Theobromine
    • Theophylline
    • Excludes: aminophylline [theophylline ethylenediamine] (E945.7)
  • E944.2 Carbonic acid anhydrase inhibitors
    • Acetazolamide
  • E944.3 Saluretics
    • Benzothiadiazides
    • Chlorothiazide group
  • E944.4 Other diuretics
    • Ethacrynic acid
    • Furosemide
  • E944.5 Electrolytic, caloric, and water-balance agents
  • E944.6 Other mineral salts, not elsewhere classified
  • E944.7 Uric acid metabolism drugs
    • Cinchophen and congeners
    • Colchicine
    • Phenoquin
    • Probenecid
• E945 Agents primarily acting on the smooth and skeletal muscles and respiratory system
  • E945.0 Oxytocic agents
    • Ergot alkaloids
    • Prostaglandins
  • E945.1 Smooth muscle relaxants
    • Adiphenine
    • Metaproterenol [orciprenaline]
    • Excludes: papaverine (E942.5)
  • E945.2 Skeletal muscle relaxants
    • Alcuronium chloride
    • Suxamethonium chloride
  • E945.3 Other and unspecified drugs acting on muscles
  • E945.4 Antitussives
    • Dextromethorphan
    • Pipazethate hydrochloride
  • E945.5 Expectorants
    • Acetylcysteine
    • Cocillana
    • Guaifenesin [glyceryl guaiacolate]
    • Ipecacuanha
    • Terpin hydrate
  • E945.6 Anti-common cold drugs
  • E945.7 Antiasthmatics
    • Aminophylline [theophylline ethylenediamine]
  • E945.8 Other and unspecified respiratory drugs
• E946 Agents primarily affecting skin and mucous membrane, ophthalmological, otorhinolaryngological, and dental drugs
  • E946.0 Local anti-infectives and anti-inflammatory drugs
  • E946.1 Antipruritics
  • E946.2 Local astringents and local detergents
  • E946.3 Emollients, demulcents, and protectants
  • E946.4 Keratolytics, keratoplastics, other hair treatment drugs and preparations
  • E946.5 Eye anti-infectives and other eye drugs
    • Idoxuridine
  • E946.6 Anti-infectives and other drugs and preparations for ear, nose, and throat
  • E946.7 Dental drugs topically applied
  • E946.8 Other agents primarily affecting skin and mucous membrane
    • Spermicides
  • E946.9 Unspecified agent primarily affecting skin and mucous membrane
• E947 Other and unspecified drugs and medicinal substances
  • E947.0 Dietetics
  • E947.1 Lipotropic drugs
  • E947.2 Antidotes and chelating agents, not elsewhere classified
  • E947.3 Alcohol deterrents
  • E947.4 Pharmaceutical excipients
  • E947.8 Other drugs and medicinal substances
    • Contrast media used for diagnostic x-ray procedures
    • Diagnostic agents and kits
  • E947.9 Unspecified drug or medicinal substance
• E948 Bacterial vaccines
  • E948.0 BCG vaccine
  • E948.1 Typhoid and paratyphoid
  • E948.2 Cholera
  • E948.3 Plague
  • E948.4 Tetanus
  • E948.5 Diphtheria
  • E948.6 Pertussis vaccine, including combinations with a pertussis component
  • E948.8 Other and unspecified bacterial vaccines
  • E948.9 Mixed bacterial vaccines, except combinations with a pertussis component
• E949 Other vaccines and biological substances
  • Excludes: gamma globulin (E934.6)
  • E949.0 Smallpox vaccine
  • E949.1 Rabies vaccine
  • E949.2 Typhus vaccine
  • E949.3 Yellow fever vaccine
  • E949.4 Measles vaccine
  • E949.5 Poliomyelitis vaccine
  • E949.6 Other and unspecified viral and rickettsial vaccines
    • Mumps vaccine
  • E949.7 Mixed viral-rickettsial and bacterial vaccines, except combinations with a pertussis component
    • Excludes: combinations with a pertussis component (E948.6)
  • E949.9 Other and unspecified vaccines and biological substances